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So what are these factors that must be taken into consideration. Unlike aldosterone, which is bound primarily by albumin, other steroid hormones bind to CBG and SHBG with high (nM) affinity and specificity, with SHBG binding the major androgens and estrogens, and CBG binding the glucocorticoids and progesterone, preferentially (Westphal 1986). Simple discontinuation of AAS use may lead to fertility recovery in a certain proportion of male users 10 , but there is little literature and considerable disagreement regarding the management of such cases.
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